Dr. Hina Altaf Dermatologist

Biological Therapy for psoriasis, urticaria and atopic dermatitis

Biological Therapy for psoriasis, urticaria and atopic dermatitis

These are drugs that target specific parts of the immune system involved in the development of a particular disease. 

Biological or biologic therapy is a treatment designed to stimulate or restore the ability of the body’s immune (natural internal defense) system to fight infection and disease. Depending on the agent, biological therapies can be given by mouth, intravenously, or as an injection.

Here’s what you need to know about biological therapy for these skin conditions.

Psoriasis: Psoriasis is a chronic autoimmune disease that affects the skin, causing red, scaly patches. Biological therapy for psoriasis involves the use of drugs that target specific parts of the immune system that are involved in the development of psoriasis. These drugs include TNF-alpha inhibitors, interleukin inhibitors, and phosphodiesterase-4 inhibitors. These drugs can be given through injection or intravenous infusion and work by blocking the immune response that leads to psoriasis symptoms.

Urticaria: Urticaria, also known as hives, is a skin condition characterized by raised, itchy, and sometimes painful welts on the skin. Biological therapy for urticaria involves the use of drugs that block specific proteins in the immune system, such as IgE, that are responsible for triggering the allergic reaction that leads to urticaria. These drugs include omalizumab and dupilumab, which are given through injection.

Atopic dermatitis: Atopic dermatitis, also known as eczema, is a chronic skin condition that causes itchy, dry, and inflamed skin. Biological therapy for atopic dermatitis involves the use of drugs that target specific proteins in the immune system that are involved in the development of atopic dermatitis. These drugs include dupilumab, which is given through injection and works by blocking the activity of interleukin-4 and interleukin-13, which are involved in the inflammation and itching associated with atopic dermatitis.

Biological therapy can be effective in treating psoriasis, urticaria, and atopic dermatitis, prurigo nodularis but it may not be suitable for everyone. It is important to talk to your healthcare provider about the potential risks and benefits of biological therapy for your specific condition, as well as any other treatment options that may be available. 

Some potential risks of biological therapy can include allergic reactions and propensity to infections. 

Your healthcare provider will work with you to determine the best treatment plan for your individual needs.

Minimal Downtime

You can return to your daily routine immediately after

Immediate Results

Results within 24 to 48 hours, with full results in 30 days

Painless Procedure

Brief period of discomfort during the injection, similar to a pinch

Results That Last

Effects typically last for several months

Biological therapy, also known as biologic treatment, is a type of systemic treatment that uses genetically engineered proteins derived from living organisms to target specific components of the immune system involved in inflammatory skin conditions like psoriasis, urticaria, and atopic dermatitis. These medications work by suppressing the immune response and reducing inflammation, thereby improving the symptoms and controlling the disease progression.
Biological therapy is typically recommended for individuals with moderate to severe forms of psoriasis, urticaria, or atopic dermatitis who have not responded well to other conventional treatments such as topical creams, phototherapy, or oral medications. Candidates for biological therapy may have significant symptoms that affect their quality of life and require a more targeted and potent treatment approach.
Several biological medications have been approved for the treatment of psoriasis, urticaria, and atopic dermatitis. These medications may be administered through subcutaneous injections or intravenous infusions, depending on the specific drug. Check with your doctor for specific treatment with medication.
While generally considered safe and effective, biological therapies can have potential side effects. Common side effects may include injection site reactions, upper respiratory tract infections, headaches, fatigue, and gastrointestinal symptoms. In rare cases, more serious side effects such as infections, allergic reactions, or immune-related complications may occur. It's important to discuss potential risks and side effects with your healthcare provider before starting biological therapy.
The duration of biological therapy varies depending on the individual and the specific skin condition being treated. In some cases, biologic treatment may be used for a fixed period, such as several months or years, while in other cases, it may be required long-term to maintain disease control. Regular monitoring and follow-up with a dermatologist are essential to assess treatment response and determine the optimal duration of therapy.

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Dr. Hinah Altaf’s clinic is currently at Gargash Hospital, 145 Umm Suqeim Street – Umm Al Sheif -Dubai.